Welcome to my blog which is dedicated to medical research on resveratrol, an extract from certain fruits which has positive medical effects.  It was discovered over forty years ago but most of the research on it has been done in the past five years.  As of this month, over 4100 articles on resveratrol have been published in medical journals.  Each month I highlight recent research and all of my information comes from pubmed.com, a branch of the National Library of Medicine which is free and open to anyone.

Heart Health:  The University of Manitoba in Canada published a paper on heart cels in rats with high blood pressure.  Half were given resveratrol and the other half not.  When heart cells are exposed to noradrenaline, a hormone produced during stress, they enlarge to produce a stronger contraction.  In the short term that is a good thing but in the long term it can ultimately lead to heart disease.  Hypertension accelerates these changes.  All of the rats were sacrificed and their heart muscle studied under a microscope.  Resveratrol prevented the noradrenaline induced enlargement of the heart muscle cells in the rats with high blood pressure.  Eur J Pharmacol July 2011

Diabetes:  In diabetics, hardening of the arteries or arteriosclerosis occurs earlier and faster than in nondiabetics.  From the University of Texas San Antonio comes a paper reporting on diabetic mice.  Half had resveratrol added to their diet and the other half did not.  They were then all fed a high fat diet and given a drug to speed up the artery-hardening process.  After 11 weeks  all the mice were killed and the arteries were examined for hard areas caled plaques.  The  resveratrol supplemented mice had 31% fewer plaques than those not supplemented.  Yet another reason to add  resveratrol to our diet.  Atherosclerosis June 2011

Heart Health:  "Calorie restriction is one of the most effective nutritional interventions that reproducibly protects protects agaist obesity, diabetes, and cardiovascular disease."  It is safe and effective. Resveratrol is the most widely studied molecule that appears to mimic calorie restriction.  The two appear to work in a similar fashion to prevent arteriosclerosis, reduce blood pressure, prevent dangerous increases in heart cell size (see the first article) and heart failure prevention.  So far all of the research has been on animals.  Because it is safe and effective, the authors suggest that it is time for human studies.  Biochim Biophys Act.  July 2011

Human Research:  From the University of Pennsylvania comes a paper explaining why most of the research on natural products like  resveratrol is done on lab animals and cell cultures.  First there is no monetary incentive to do human research using a product that other companies have access to.  There is no patent protection, and therefore extremely risking profit potential. Secondly, because  resveratrol is not patentable , nutriceutical companies make a product blended with other natural products to make their own proprietary blend making it extremely difficult to compare their data with that from other labs and othe companies using different blends or even pure  resveratrol.  Thirdly, natural supplements commonly have multiple targets with different dose response profiles, tissue distributions, and modifiers.  The few human studies "combined with a growing list of animal studies provide a strong justification for further study."  Whether that includes human research is uncertain.  J Gerontol A Biol lSci Med Sci July 2011

Cancers:  There were two papers published on  resveratrol and two cancers that are difficult to treat.  From Southeast University Nanjing, China is a study of pancreatic cancer cells in cultures and how  resveratrol speeds up cell death.  There was no toxicity in normal pancreatic cells.  The more rapid cancer cell deaths hold promise as a new way to treat pancreatic cancer.  From the Fourth Military Hospital in China comes an article on glioblastoma cells.  This is a type of brain cancer that is also difficult to treat successfully.  In cultures of glioblastoma cells, when  resveratrol is added it not only speeds up cell deaths but also slows the growth in living cancer cells.  This all occurred without toxicity.  Chin Med J June 2011  Oncol Rep July 2011

Diabetes:  From Rhode Island Hospital, Providence comes a paper on Yorkshire miniswine.  The animals were divided into three groups.  One was given a regular diet, another a high fat diet, and the third a high fat with  resveratrol.  Blood sugars and insulin levels were measured.  The high fat group had increased insulin and blood sugar levels over the other two groups.  All the animals were then euthanized (killed) and muscle and liver tissues were studied.  The conclusion was that  resveratrol "positively influences sugar metabolism pathways in liver and muscle and leads to improved sugar control in swine"  Arch Surg May 2011 556-64

Diabetes:  A smilar study was done at the German Food Research Center for Food Chemistry in Freising.  Rats were studied. Half were supplemented with  resveratrol and all were fed a high carbohydrate diet.  The  resveratrol group had a 35% decrease in sugar and a 41% decrease in insulin over the non-treated group.  0ol Nutr Food Res July 2011

Prostate Cancer:  A paper from the University of Mississippi looked at how  resveratrol helps prevent the onset of  prostate cancer.  Prostate cells in culture dishes were exposed to a chemical that causes normal prostate cells to turn into cancer cells.  Half were pretreated with  resveratrol.  Through a compound called microRNA, the  resveratrol caused a decrease in the cancer causing effect of the carcinogen and increased tumor suppression by the normal cells.  Whether the microRNA is the actual pathway is unclear but my bottom line is that fewer normal cells turned into cancer cells. Mol Nutr Food Res June 2011

As you can see,  resveratrol can be used to prevent certain conditions like hardening of arteries, and can also be used to control diabetes, prevent or treat cancers and protect the heart.  Remember that Shaklee's  resveratrol, VIVIX, is ten times as potent as other products out there.  Food for thought for the health conscious perso.

Until next time,

Dr Bob

Male Health

MALE HEALTH

Welcome once again to those who share an interest in resveratrol. As you know, resveratrol is an extract of various fruits such as blueberries and grapes. It’s various properties studied in labs include antioxidant, anti-inflammatory, anti-aging, blood sugar lowering, cardioprotective, neuroprotective, anticancer, and improved healing. The following are summaries of articles from medical journals on resveratrol from the National Library of Medicine.

TESTOSTERONE From the Chongbuk National University in Korea comes a study of rabbits with resveratrol added to their diet. After 28 days on resveratrol, the rabbits had an increase in blood testosterone of 51.6%, and testicular sperm counts of 15.8% and a 23.3% in epididymal sperm motility. These same rabbits also had stronger erections. There is a positive effect on the reproductive function in rabbits on resveratrol. Arch Pharm Res 2008 June; 31 (1) 83-87

TESTOSTERONE Rats were studied at the University of Barcelona in Spain. Half of a group of adult male rats were fed resveratrol and the other half not. After 90 days the participants were sacrificed and the testicular tissue was studied under the microscope. The resveratrol group had about twice the sperm count as the control group with no difference in the quality of the sperm. The resveratrol group also had higher testosterone levels, and there no side effects from the resveratrol. J Nutr Apr 2005 135: 757-60

PROSTATE CANCER From the University of Mississippi comes a study on prostate cancer. They studied human prostate cancer cells growing as a culture and the microRNAs they contain. Some microRNAs stimulate cancer cells to grow faster, and others slow the growth. In cells exposed to resveratrol the growth microRNAs are decreased and the suppression microRNAs are increased resulting in a much slower growth rate. Mol Food Res 2011 Aug; 55 (8): 1219-1229

CANCER The M D Anderson Cancer Center published a review article about tumors developing resistance to chemotherapeutic drugs, so they are looking for effective chemosensitizers, drugs making the tumor cells more sensitive to chemo. Resveratrol can sensitize tumor cells to a variety of chemotherapy drugs. Tumor cells in cell cultures which have been chemosensitized include lung cancer, acute myeloid leukemia, prostate cancer, oral epidermoid cancer, pancreatic cancer, promyelocytic leukemia and multiple myeloma. Their conclusion was that resveratrol can be used to sensitize tumor cells to standard cancer drugs. Ann NY Acad Sci 2011 Jan; 1215: 150-60

PROSTATE CANCER At the University of Texas San Antonio, human prostate cancer cells were implanted into mice. Half of the mice were pre-fed resveratrol. The mice were later killed and examined, looking for tumor size, and the number of metastases. The resveratrol group had smaller tumor sizes and fewer metastases than the control which did not receive resveratrol. None of the mice survived the study and it is a stretch to say that resveratrol should be used in prostate cancer patients, but it can’t hurt. PLoSOne 2010 Dec 28; 5(12): e15627

PROSTATE CANCER I know you are seeing a pattern here, but I am a urologist, so indulge me. We’ve seen articles on treating existing prostate cancer. Let’s look at something that might prevent prostate cancer. There is a virus called SV40 Tag which will cause prostate cancer when injected into mice. At the University of Alabama, half of a group of mice were fed resveratrol and the other half not. They were then all injected with SV40 Tag. The mice were then killed 12 or 30 weeks after the injection and checked for prostate cancer. You guessed it. The resveratrol group had more mice without prostate cancer than the group not on resveratrol. There was a significant number of cancers that were prevented. This paper then went into the various pathways involved in cancer prevention. Prostate 2009 Nov 1; 69(15) 1668-82

In this blog I have concentrated on male health. Prostate cancer is the most common cancer in men. The risk goes up if there is prostate cancer in a relative. As noted in other blogs, there are a variety of sources of resveratrol on the market. Vivix from the Shaklee Corporation is ten times stronger than its closest competitor. Why not go for the best.

Until the next time,

Dr Bob

COPD, Non Food Source of Resveratrol, Obesity, Diabetes and Kidney Failure, and more....

Welcome back to my blog which highlights the research done on the natural product resveratrol , a compound extracted from certain fruits and nuts (that reminds me of an old California joke where I grew up). There has been considerable research on resveratrol with 3972 articles published on resveratrol in medical journals as of April 19, 2011. The studies continue to use mostly lab animals or cell cultures but this month there is another human study, sort of. Any of these articles can be viewed directly by going on www.pubmed.com and search by topic or citation. I hope the following will help you appreciate the potential health benefits of resveratrol .

1. COPD From the University of Cologne, Germany comes a paper on Chronic Obstructive Pulmonary Disease, which includes chronic bronchitis and emphysema. This is a common lung disorder mostly among people with a history of smoking. This is the “sort of” human study. Lung cells were taken from living smokers, ex-smokers, and never smokers. In many people, steroids do not help with acute flare-ups of COPD but are used anyway because there is not much else that works any better. Steroids, like prednisone, are not without side effects and complications, especiall if used long term (weeks or months). In this study the lung cells of the 3 groups were each divided in half. Half of each was exposed to resveratrol and the other half to a steroid. All were then treated with a bacterial toxin. The steroid group showed more reaction to the toxin than the resveratrol , indicating that resveratrol could be a safe and effective alternative for lung inflammation in a COPD patient. (Basic Clin Pharmacol Toxicol, Mar 29, 2011)

2. Non-food source of resveratrol State University of New York, Buffalo At this time there is promising research on developing a strain of bacteria that will produce diesel fuel (bio-diesel) as a by-product. Similarly there is research on developing a strain of bacteria in New York and Germany which will produce resveratrol , which ideally make producers less dependent on natural sources such as fruits and nuts. Now that goal is a hope and a dream. If it works, no one knows if the end result would be worse than, same as, or better than the product of Mother Nature. There is the possibility of an alternative source of resveratrol in the future. (Appl Environ Microbiol Mar 25, 2011)

3. Obesity Yonsei University, Seoul, South Korea (where I was a visiting professor 1989-1990) A group of rats was divided into a resveratrol treated group, and a placebo treated group. They were all fed a high fat diet. The resveratrol group had 48% less weight gain and 58% less fat pad weight gain, and a lower increase in the rise in cholesterol, triglycerides, and blood sugar. The paper went on to discuss the various chemical pathways that caused these results. Whatever the reason, the results are definitely encouraging. Keep in mind we are not recommending resveratrol in order to partake in your own personal high fat diet experiment. There was still weight gain and fat pad weight gain in the resveratrol rats. (Biochem Pharmacol Mar 31, 2011)

4. Diabetes and kidney failure Oxidative stress plays a crucial role in progression of kidney damage in diabetics with high blood sugars. A group of diabetic rats was given a chemical that causes kidney damage. Half that group was fed resveratrol and the other a placebo. In the resveratrol group there was a significant normalization of kidney function. The mechanism was that there is a kidney protective effect by the anti-oxidant resveratrol in reducing the oxidative stress in the kidneys resulting from high blood sugars. (Biochim Biophys Acta Mar 23, 2011)

5. Liver protection From Serampore College, West Bengal, India comes a paper that affects only a small number of people but I found it interesting. In people with high fever or heat injuries such as sunstroke and heat exhaustion, there is liver damage. Again, rats volunteered and were subjected to high temperatures. Then half the rats were given resveratrol and the other half nothing. The resveratrol group had a dramatic improvement in liver function with rapid recovery. Resveratrol appears to be “an effective antidote in the ttreatment of heat induced(liver) malfunction”. (Toxicol Mech Methods Mar 23, 2011)

6. Heat stability From the University of Split in Croatia looked at the heat stability of resveratrol . For those of you who want to get their resveratrol from red wine and not just Shaklee’s Vivix, a studt was done where red wine was heated to boiling until all of the alcohol was cooked off. Then it was colled, and the vasodilation effect was measured and compared with the effect of unheated resveratrol . There was no difference. This means resveratrol is heat stable and can be used for cooking, and may not be heat resistant during storage and shipping. (J Cardiovasc Pharmacol Mar 17, 2011)

I hope you get some benefit from these reviews. I am constantly hearing about this one small corner in the overall work of medical research. All of this is encouraging in the use of resveratrol for a variety of health conditions, or just for prevention and wellness. Until next time, Dr. Bob

Cancer, Diabetes, Menstral Cramps, and More

The following articles have been published in medical journals around the world. They are about the anti-oxidant, anti-inflamatory neuroprotective, cardioprotective ingredient of the vegetable world called resveratrol. It offers many health benefits for many people. Keep in mind that Shaklee's resveratrol in the form of Vivix is ten times as powerful as other resveratrol products on the market. Remember, most research is done with animals and in test tubes. In this issue, we have an article on human subjects. We continue to receive personal success stories which are anecdotal but in such a large number, I can't help but be impressed. Let's look at a few recently published articles.

1. Testing: From the University of Jaen in Spain comes a report on a new spectrofluorimetric method of measuring the content of resveratrol in any sample. It is quicker and cheaper than anything that exists now. To me, this means that we can measure the amount of resveratrol in the raw ingredients prior to formulation to make the most powerful product. (Anal Chim Acta 18 Mar 2011)

2. Cancer: From the University of Nebraska is an article on cancer. Some people have high levels of something called estrogen-DNA adducts which are a result of the unbalanced metabolism of estrogen. Yes, men have small amounts of estrogens as do women have small amounts of testosterone. In this a study on people with higher levels of estrogen-DNA adducts, these levels can be lowered by specific anti-oxidants, one of which is resveratrol. Women at high risk for breast cancer or diagnosed with breast cancer, men with prostate cancer, and men with non-Hodgkin's lymphoma would benefit from lowering of this adduct. Vivix offers a natural and safe way to achieve this goal. (J Steroid Biochem, Mol Biol 9 Mar 2011)

3. New Source: From Monash University in the "land that wastes nothing" comes a report of a new source of resveratrol. Most v comes from fruits such as grapes and blueberries. In Australia they were able to extract resveratrol from peanut press waste. That would be the goo left over from making peanut butter. While there is not a lot of resveratrol per pound, the source is free and earth-friendly. Well done mate. (J Agric Food Chem 10 Mar 2011)

4. Diabetes: From the University of Pecs in Hungary comes a human study on diabetics. Resveratrol has improved the control of blood sugar in a variety of lab animals. In this study a group of diabetic people was divided into a group on resveratrol and a group who were not. In a four week study, before and after the second and fourth week, insulin resistance and sensitivity were measured. After the forth week, the resveratrol group had a significant decrease in insulin resistance. This is the first study showing that resveratrol improves insulin sensitivity in humans. This may be due to a resveratrol induced anti-oxidant affect that leads to a more efficient insulin signaling. (Br J Nutr 9 Mar 2011)

5. Another source: From Belgium (think New Belgium Fat Tire) comes a study showing that grapes and red wine are not the only source of resveratrol. Resveratrol is present in red sorghum and is also in beer made with red sorghum as its grain source. This is good news for beer afficianados, but the amount of resveratrol is much less less than in Shaklee Vivix. (J Agric Food Chem 7 Mar 2011)

6. Menstrual cramps: Taiwan published a paper on uterine contraction in rats. While this may not be of interest to many people, it holds the promise of more comfortable periods for many women. Chinese medicine focuses more on natural and herbal treatments than western medicine. This is the first article looking at the effect of resveratrol on uterine smooth muscle. Rats, half of which were treated with resveratrol and the other half not, were "separated" from their uteri (rat hysterectomy) and subjected to a drug that causes muscle contractions of the uterus (cramps). The resveratrol treated rat uteri had much less contraction than the non-treated. It is a far stretch to say that V or Vivix would help with menstrual cramps, but it will be years before human research catches up with animal studies. It would only take one or two months to find out if Vivix would decrease the severity of menstrual cramps. If it helps, that's great. If it does not, the money-back guarantee is still there. (Endocrinology 1 Mar 2011)

I hope at least some of this is of interest to you. More next time, and I will try to be more productive. Until next time.

Dr. Bob

Women's Health, Prostate Cancer, Arthritis, Obesity and More

Have you heard the saying that if you want a good worker, look for someone who is already busy? It has been too long since my last blog, so I wait until the busiest time of the year to put this out. And speaking of the time of year, I wish each of you a very Merry Christmas. I also wish for each of you. As a reminder, this blog is about research published in medical journals on resveratrol. If you wish to do your own research, go to www.pubmed.com.

1. Women's health was the subject of this paper. Note that it was published almost 10 years ago. There are a variety of changes the female body goes through after menopause and one way to prevent or deal with them is hormonal replacement therapy. Unfortunately the more popular replacement therapies are associated with potential side effects and complications such as blood clots, strokes, and gallbladder disease, as well as endometrial, uterine, and breast cancers. This study showed that "resveratrol supplementation may be an alternative conventional hormone replacement therapy for cardioprotection and osteoporosis prevention and may confer other potential health benefits in women." (Drugs Exp Clin Res, 2001 233-48)

2. Prostate cancer is the most common cancer in men. Early detection and treatment which uses multiple modalities result in more successful treatment and fewer cancer deaths. This paper is looking at prostate cell cultures, cancer cells growing in a glass dish. One treatment is using hormone therapy. The problem with hormonal therapy is that eventually the treatment no longer works as the cancder cells become hormonally resistant. Built into every cell is a message that tells the cell when to die (apoptosis). Resveratrol tells the cancer cells to die early. This has the potential of helping prostate cancer patients who are responding responding to hormonal therapy or not. (Anticancer Res Sept 2007)

3. Arthritis is a common problem that all adults suffer from sooner or later. It is called osteoarthritis or degenerative joint disease. In this study from Turkey, half of a group of rabbits was put on resveratrol and the other not. They all then had a had a toxic substance injected into their knees which damages cartilage, simulating arthritis. The group on resveratrol had significantly less joint damage. This has the potential of decreasing arthritis in all of us. (Inflammation Apr 2007)

4. Obesity is associated with a variety of other health issues such as arthritis, diabetes, elevated cholesterol or triglycerides or free fatty acids, and low insulin levels (diabetes). A group of obese Zucker rats was given resveratrol and they had a decrease in the blood fats and an improvement in blood sugars. Resveratrol has the possibility of helping diabetics both in sugar control and elevated blood fats. (Biochem Pharmacol Dec 2008)

Remember, Shaklee's resveratrol, vivix, is ten times as potent as other products out there. Here is to your health.

Dr Bob

Facinating Resveratrol Reasearch on Humans

Welcome back to my blog dedicated to sharing knowledge of resveratrol and its benefits with anyone interested. As usual, the articles all come published medical journals from all around the world. I have posted some testimonials as well. If you are new to this blogsite, I would urge you to go to the very bottom, as that is my first blog, and work you way up. I will continue to try and keep it pithy and brief.


Many people try to keep the best for last, but I can't wait. Most research on resveratrol is done in test tubes or in lab animals. My first article is on real people and fascinating.

Learning--From the United Kingdom comes a report where they looked at the effects of oral resveratrol on learning performance and blood flow in the brain in healthy adults. The participants received 1. a placebo, 2. 250 mg resveratrol (2 1/2 tsp Vivix), or 3. 500 mg resveratrol (5 tsp of Vivix). 45 minutes later they were given a series of tests that required learning skills. Blood flow in the brain was also studied. The results were that the 500 mg group showed an increase in blood flow to the brain as well as the amount of oxygen removed from the blood. The 250 mg group showed less increase in blood flow but still better than the placebo group. This was confirmed by shuffling the participants and running the study again on a different day. A single dose of resveratrol can improve learning and cerebral blood. Imagine taking it before a class. (Am J Clin Nutr Mar 2010)

Depression--The University of Florida Gainesville on the antidepressant effect of resveratrol, dealing with both the serotonin and noradrenaline systems. These are natural chemicals in the brain involved in chemical depression. Resveratrol was fed to half of a group of mice. They were all put through a series of "despair tests" designed to create depression in mice. The resveratrol group did dramatically better and had higher levels of serotonin and noradrenaline in their brains. (Eur Neuropsychoparmacol Mar 2010)

Chronic Ulcerative Colitis and Colon Cancer--Resveratrol has anti-inflammatory, cardioprotective, and cancerprotective properties. Chronic Ulcerative Colitis (CUC) is an inflammatory disease os the digestive tract associated with a high risk of associated colon cancer. It can be very difficult to treat. At the University of South Carolina, a chemical was fed to mice which causes CUC and subsequent colon cancer. Half of the mice were fed resveratrol in advance. 80% of the non-resveratrol mice got CUC and subsequent colon cancer. 20% of the resveratrol group got CUC. The resveratrol mice who got tumors got fewer of them. And this was achieved with a product that is non-toxic and inexpensive. (Canc Prev Res Mar 2010)

Chemotherapy and Protecting the Kidneys--As a Urologist (see Blog 1) I believe in protecting kidneys. Many standard chemotherapy agents have the potential to damage the kidneys, thus limiting their further use. One commonly used drug is cisplatin, and one factor that limits its use is kidney damage. At the University of Sao Paulo in Brazil, rats were given cisplatin in a dose that would damage kidneys. Because resveratrol has both antioxidant and anti-inflammatory properties, it was given to half of the rats prior to the chemo-therapy. Several days later the rats were sacrificed and their kidneys were examined under a microscope. You guessed it. The resveratrol group had considerably less damage. If someone you know was about to get cisplatin, it would be a good idea to suggest resveratrol.

I hope part or all of this is of interest. I still believe that Vivix made by Shaklee Corp is the best and most potent source of resveratrol available. Until next time.

Dr Bob

From prescription pills, overweight, endometriosis, fibromyalgia and depressed to loads of energy and the best pregnancy ever!

In addition to finding all of our Vivix research on Pubmed.com, I also like to go to Bob's Files where a man named Bob Ferguson, who is also a part of Shaklee, posts a lot of testimonies and medical research. I came across this today and thought you would enjoy reading it. Yet again, this is one more of thousands of reasons to put the best stuff on earth into our bodies.

ANGIE LOBUE'S TESTIMONY -

When I started Shaklee, I was in my worst health. I was on numerous prescriptions pills, overweight, depressed and full of anxiety (I'd just quit a job that I loved due to poor health), had restless leg syndrome (RLS), irritable bowel syndrome (IBS), GERD, high blood pressure and cholesterol, and was in excruciating pain from fibromyalgia. I was sick and tired of being sick & tired.

With Shaklee and other major lifestyle changes, I was able to stop all prescriptions but one, lose 30 lbs. on the Shaklee Weight Management, lower blood pressure and cholesterol naturally, have more energy, and feel great physically and mentally. After about a year, I was able to even end the painful fibromyalgia.

Mitchell (my husband) watched the transformation and joined the Shaklee bandwagon as well. He lost 16 lbs., was able to quit several prescriptions, lower cholesterol, and had more energy.

However, the biggest testimony to Shaklee comes in a precious little bundle. Years ago, due to endometriosis, we'd been told that we couldn't have children naturally. After 7 months of Shaklee, losing weight, ridding our home and bodies of toxins, and becoming healthier than ever, we got the biggest blessing of all....I was pregnant 13 years into our marriage and at the age of 37.

I had the best pregnancy using Shaklee supplements as my prenatals. Then, for reasons only God knows, our daughter entered this world 2 months early. She was only 3 lbs. 13 oz. However, she didn't have to be intubated, they wanted to send her home before even 4 lbs. Because she was so healthy, and she was only in the NICU for 16 days. We heard over and over, "This isn't the norm for a 32-weeker."

Our daughter is now 2 years old and has been on the Shaklee Infant Vitamins since 4 months of age. She's been extremely healthy, has never had an ear infection, and has never been on antibiotics. She loves her "lakee".

I have lost all of my "baby fat" plus extra-- 35.5 lbs. and 36 overall inches (and counting) with Shaklee's safe CINCH inch loss program.

We're so thankful that Shaklee came into our lives. It has been a blessing that has impacted our family, future, and health profoundly. We not only love what the amazing products do for our family but also the extra income it brings.

So thankful for Shaklee,

Angie Lobue