HEART DISEASE, DIABETES, COLORECTAL CANCER, ADHESIONS

Heart Disease, Diabetes, Colorectal Cancer, Adhesions

I salute your interest in Resveratrol and clinical studies associated with it.  If you are fairly new to this site, I would suggest scrolling down to the very first posting which is at the very bottom or end of this blog.  It gives background to this site.  For the record, there are now 4919 scientific articles on Resveratrol published in medical journals in the National Library of Medicine.  That is where the following articles come from, www.pubmed.com.

HEART DISEASE  From the Russian Academy of Medical Science in Moscow comes a review article on dietary polyphenols, of which Resveratrol is a part.  They showed that several studies link a decrease in cardiovascular disease (CVD) mortality rate with certain diets.  Diets rich in vegetables, fruits, unrefined cereals, legumes, nuts, garlic, olive oil and red wine.  Mediterranean diets incorporate the above and are associated with lower CVD mortalities. Resveratrol is a part of this cardioprotective action.

Bratisl Lek Listy 2012: 476-80

DIABETES  A study from a pharmacy college in India was published using human subjects with Type II diabetes on oral medications.  Half of the 62 patients were given their usual oral medications and the other half received 250 mg per day along with their regular medications for three months.  The Resveratrol group had a significant improvement in Hemoglobin A1c (a measure of blood sugar control), decreased blood pressure, and decreased total cholesterol.  There was no change in body weight or HDL (the good cholesterol).  The conclusion was that “Resveratrol is thus found to be effective in improving glycemic control” and may “provide  a potential adjuvant for the treatment and management of diabetes”.

Nutr Res 2012 July 537-41

COLORECTAL CANCER Another human study. A researcher from St James University Hospital in West Yorkshire, UK published his study of patients with Familial Adenomatous Polyposis  (FAP).  This a group of people who have inherited a gene which causes multiple polyps in the colon which in turn increases the risk of getting full-blown colorectal cancer.  Half of a group of these people were given supplemental Resveratrol and the other not.  The group treated with with the nutriceutical product had fewer and smaller polyps on colonoscopy than the untreated group.  Phase III trials are starting on this subject.

Recent Results Cancer Res 2012: 143-56

COLORECTAL CANCER  Colon cancer ranks third in cancer related mortalities, and certain phytochemicals including Resveratrol are being studied to prevent the onset of colon cancer.  A group from Meharry Medical Medical College in Nashville, TN took a group of mice and fed half with a chemical (benzo-a-pyrene) which causes colon cancer, for 60 days.  The other half was fed the chemical along with Resveratrol for 60 days.  The mice were then killed and the number of tumors in each animal was counted.  The Resveratrol group had fewer tumors.  They also had fewer areas of pre-cancer changes and under the microscope Resveratrol sped up cancer cell deaths  and decreased cell growth

J Nutr Biochem 2012 Aug.

ADHESIONS  At the Ankara Education and Research Hospital in Turkey, post-operative adhesions were studied.  This formation of troublesome scar tissue is a common problem after pelvic surgery.  A group of of rats was divided into thirds.  One third got Resveratrol 10 days before and 20 days after surgery.  The second third received Resveratrol orally for 20 days after surgery and the remainder received nothing.  They all were operated on in the pelvic area.  The rats were then killed 3 weeks later and studied for the number of adhesions and the severity of the adhesions.  Both Resveratrol groups did much better than the non- Resveratrol group.  The first group did much better with Resveratrol given before and after surgery than the second group.  Giving Resveratrol before and after pelvic surgery is an effective way to prevent or minimize adhesions after pelvic surgery in rats.

Hum Fertil 2012 Aug 9

Hopefully something in these articles was of interest.  We are starting to see more human studies and Resveratrol research is looking at a wider variety of places where it can be beneficial.  As always, I still believe Shaklee’s Vivix to be the most potent, purest,and most effective source of Resveratrol.

Until next time,

Dr Bob

PREGNANCY, CORONARY ARTERY DISEASE, BREAST CANCER, VERTEBRAL DISC DISEASE, DIABETES, LEARNING, CORN SYRUP, COLON CANCER

Welcome back to those who are not new to this post.  In these blogs, I review articles publishes on Resveratrol from around he world.  As mentioned previously, they are posted by the National Library of Medicine found at www.pubmed.com.  Some of my blogs are on specific subjects.  This one is on randomly selected subjects.  As they say on IRON CHEF AMERICA, “enjoy”.

PREGNANCY  From the University of Alberta, comes a study on hypoxemia, which is low oxygen in the blood, during pregnancy.  This can result is serious negative effects on the fetus.  Pregnant rats were put on Resveratrol and then allowed to breathe air with half of the oxygen levels as normal air.  The pregnant rats had almost a complete reversal of miscarriages compared to a group of hypoxemic pregnant rats not on Resveratrol.  Resveratrol crosses the placenta and has a beneficial effect on the fetus directly.

Placenta 2012 Feb

CORONARY ARTERY DISEASE  From the Xuzhou Medical College in China comes a study on coronary artery disease.  A group of pigs was divided into three smaller groups--Resveratrol,  nitroglycerin and a control group.  Each pig then had a coronary artery blocked by a balloon, simulating a heart attack.  After the heart attack, the coronary which had been blocked was injected either with Resveratrol, or Nitroglycerin.  The blood flow in the heart muscle was then measured and was much greater in the Resveratrol treated heart.  The conclusion was that Resveratrol could significantly improve blood flow through heart through alternative vessels.  The logical extension would be to inject Resveratrol into the heart of a person having a heart attack.  It appears to be safe but we may never see this done in our lifetime.

Zhonghua Xin Xue Guan Bing Za Zhi 2011 Oct pp946-9

BREAST CANCER  The University of North Dakota School of Medicine published a complex paper on the chemical causes of breast cancer and how Resveratrol at different doses can prevent some of the chemical changes that can result in less breast cancer.  I include this study because there was a benefit from Resveratrol and it is a human study.

Nutr Cancer 2012 Feb

VERTEBRAL DISC DISEASE  From Rush University Medical Center in Chicago comes a study of bovine (cow) and spinal cartilage (discs).  This was a cell culture study where cells from the spinal discs of cows were exposed to Resveratrol.  There was a potent stimulation of ceil growth which could slow the progression of the degeneration of discs.  This suggests “Resveratrol may have considerable promise in the treatment of disc degeneration.

Spine 2008 Nov pp 2586-95

DIABETES  The College of Medicine at Chang Gung University looked at muscle wasting in diabetics.  Rats became diabetic after being exposed to streptozotocin. Resveratrol was then given to half of the rats and muscle mass was compared to diabetic rats not on Resveratrol.  There were multiple pathways in which there was loss of muscle mass in the diabetic rats on Resveratrol, along with improved energy metabolism.

Am J Phyiol Endocrinol Metab 2011 July

AGE RELATED LEARNING DISORDERS  The Miami VA Hospital researched the subject of learning disorders in the elderly.  There are a variety of causes of the condition called dementia, but one of them was a poor blood supply to the brain.  There is a chronic inflammation of blood vessels that can change the blood supply to brain cells.  A variety of berries and grapes were studied and there was a common beneficial compound in all of the natural products, which improved blood supply—Resveratrol.  In several studies, learning in elderly rats improved on Resveratrol.  It worked best if rats were started on it before learning difficulties began.  We have seen the neuroprotective effects of Resveratrol in a variety of brain problems.

Br J Nutr 2012 Apr

HIGH FRUCTOSE CORN SYRUP  At the Gazi Institute in Ankara, Turkey, high fructose corn syrup was studied because it is a common food additive in a large number of food products.  It turns out that high fructose corn syrup consumption causes increased triglycerides, increased VLDL, and increased insulin and blood pressure. Resveratrol restored the high fructose corn syrup changes to normal. Resveratrol “has a protective potential against the harmful consequences of high fructose corn syrup consumption.”

Food Chem. Toxicol 2012 Mar

COLON CANCER  Finally, from the University of Barcelona, came a review article on the protective effects of Resveratrol from the changes that cause colon cancer. Resveratrol will slow the growth of cancer cells and increase the death rate of these same cells.  It is also effective in preventing the onset of colon cancer in lab animals exposed to chemicals that cause colon cancer.  It also decreases pre-cancerous changes, and in lab animals on Resveratrol which get colon cancer, the cancers are smaller and fewer in number.  Again, a natural product exists to offset the risk of one of the more common cancers.

Pharmacol Res 2012 Mar

I know this is a real hodge podge but it is also a tasting from a variety of different issues. Resveratrol, the active ingredient in Shaklee’s VIVIX can improve your health in a variety of different ways.